Wall Street Analyst Downgrade Prothena Corporation plc [PRTA]. What else is Wall St. saying

Prothena Corporation plc [NASDAQ: PRTA] gained 0.88% on the last trading session, reaching $5.75 price per share at the time.

If compared to the average trading volume of 1.45M shares, PRTA reached a trading volume of 4971532 in the most recent trading day, which is why market watchdogs consider the stock to be active.

Here is what top equities market gurus are saying about Prothena Corporation plc [PRTA]:

Based on careful and fact-backed analyses by Wall Street experts, the current consensus on the target price for PRTA shares is $24.29 per share. Analysis on target price and performance of stocks is usually carefully studied by market experts, and the current Wall Street consensus on PRTA stock is a recommendation set at 2.22. This rating represents a strong Buy recommendation, on the scale from 1 to 5, where 5 would mean strong sell, 4 represents Sell, 3 is Hold, and 2 indicates Buy.

BofA Securities have made an estimate for Prothena Corporation plc shares, keeping their opinion on the stock as Underperform, with their previous recommendation back on May 28, 2025. The new note on the price target was released on May 27, 2025, representing the official price target for Prothena Corporation plc stock. Previously, the target price had yet another raise to $6, while Jefferies analysts kept a Hold rating on PRTA stock.

The Average True Range (ATR) for Prothena Corporation plc is set at 0.48, with the Price to Sales ratio for PRTA stock in the period of the last 12 months amounting to 2.24. The Price to Book ratio for the last quarter was 0.71, with the Price to Cash per share for the same quarter was set at 7.76.

Trading performance analysis for PRTA stock

Prothena Corporation plc [PRTA] gain into the green zone at the end of the last week, gaining into a positive trend and gaining by 12.75. With this latest performance, PRTA shares dropped by -22.30% in over the last four-week period, additionally sinking by -55.04% over the last 6 months – not to mention a drop of -71.83% in the past year of trading.

Prothena Corporation plc [PRTA]: A deeper dive into fundamental analysis

Operating Margin for any stock indicates how profitable investing would be, and Prothena Corporation plc [PRTA] shares currently have an operating margin of -100.49% and a Gross Margin at 97.39%. Prothena Corporation plc’s Net Margin is presently recorded at -79.94%.

Return on Equity for this stock declined to -19.72%, with Return on Assets sitting at -19.72%.

Prothena Corporation plc [PRTA]: An earnings per share (EPS) analysis

The progress of the company may be observed through the prism of EPS growth rate, while Wall Street analysts are focusing on predicting the 5-year EPS growth rate for PRTA. When it comes to the mentioned value, analysts are expecting to see the 5-year EPS growth rate for Prothena Corporation plc go to -9.84%.

An analysis of Institutional ownership at Prothena Corporation plc [PRTA]

The top three institutional holders of PRTA stocks are: ECOR1 CAPITAL, LLC with ownership of 11.58 million shares, which is approximately 21.5453%. FMR LLC, holding 8.07 million shares of the stock with an approximate value of $$166.48 million in PRTA stocks shares; and FMR LLC, currently with $$87.46 million in PRTA stock with ownership which is approximately 7.881%.

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